Heme oxygenase-2/adiponectin protein–protein interaction in metabolic syndrome
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چکیده
منابع مشابه
Obesity/Metabolic Syndrome Adipocyte Heme Oxygenase-1 Induction Attenuates Metabolic Syndrome in Both Male and Female Obese Mice
Increases in visceral fat are associated with increased inflammation, dyslipidemia, insulin resistance, glucose intolerance, and vascular dysfunction. We examined the effect of the potent heme oxygenase (HO)-1 inducer, cobalt protoporphyrin (CoPP), on regulation of adiposity and glucose levels in both female and male obese mice. Both lean and obese mice were administered CoPP intraperitoneally ...
متن کاملAdipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice.
Increases in visceral fat are associated with increased inflammation, dyslipidemia, insulin resistance, glucose intolerance, and vascular dysfunction. We examined the effect of the potent heme oxygenase (HO)-1 inducer, cobalt protoporphyrin (CoPP), on regulation of adiposity and glucose levels in both female and male obese mice. Both lean and obese mice were administered CoPP intraperitoneally ...
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Metabolic diseases, such as insulin resistance, type II diabetes, and obesity, are associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of metabolic diseases, agents and cellular molecules that can modulate these stress responses are emerging as p...
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hydrogen donor: oxygen oxidoreductase (í µí»¼-methene hydroxylating, decycliz-ing)) catalyzes the rate limiting the step in the oxidative catabolism of heme to generate biliverdin-IXí µí»¼, which is subsequently converted to bilirubin-IXí µí»¼ by cytosolic NAD(P)H-dependent biliverdin reductase [1]. This reaction, which requires molecular oxygen as well as electrons from NADPH-dependent cytochr...
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A heme-dependent conformational rearrangement of the C-terminal domain of heme binding protein (PhuS) is required for interaction with the iron-regulated heme oxygenase (HemO). Herein, we further investigate the underlying mechanism of this conformational rearrangement and its implications for heme transfer via site-directed mutagenesis, resonance Raman (RR), hydrogen-deuterium exchange MS (HDX...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2013
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2013.02.037